Long polypeptide 310-helices at atomic resolution
نویسندگان
چکیده
منابع مشابه
310 helices in channels and other membrane proteins
Structures of three potassium channels of the six-trans-membrane (TM) helix type, a ligand-gated channel, and two voltage-gated channels were solved recently by x-ray crystallography (Long et al., 2005a,b, 2007; Clayton et al., 2008). In all three channel structures, the fourth TM segment (the voltage sensor in the voltage-gated channels) of each subunit adopts a 3 10-helical confor-mation over...
متن کاملThe Ribosome at Atomic Resolution
The 2009 Nobel Prize in Chemistry has been awarded to Venki Ramakrishnan, Tom Steitz, and Ada Yonath for crystallographic studies of the ribosome. The atomic resolution structures of the ribosomal subunits provide an extraordinary context for understanding one of the most fundamental aspects of cellular function: protein synthesis.
متن کاملPolypeptide helices in hybrid peptide sequences.
A new class of polypeptide helices in hybrid sequences containing alpha-, beta-, and gamma-residues is described. The molecular conformations in crystals determined for the synthetic peptides Boc-Leu-Phe-Val-Aib-betaPhe-Leu-Phe-Val-OMe 1 (betaPhe: (S)-beta3-homophenylalanine) and Boc-Aib-Gpn-Aib-Gpn-OMe 2(Gpn: 1-(aminomethyl)cyclohexaneacetic acid) reveal expanded helical turns in the hybrid se...
متن کاملSerpin latency transition at atomic resolution.
Protease inhibition by serpins requires a large conformational transition from an active, metastable state to an inactive, stable state. Similar reactions can also occur in the absence of proteases, and these latency transitions take hours, making their time scales many orders of magnitude larger than are currently accessible using conventional molecular dynamics simulations. Using a variationa...
متن کاملReviewProtein Folding and Unfolding at Atomic Resolution
resolution. The relevance of folding in vitro to folding in vivo was established using two small proteins, CI2 (chymotrypsin inhibitor 2, 64 residues) and barnase (BaAlan R. Fersht1,3 and Valerie Daggett2,3 1 Department of Chemistry and MRC Centre for Protein Engineering cillus amylolquiefaciens Rnase, 110 residues), the two University of Cambridge proteins on which many of the modern methods o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.7.1988